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High precision aerosol atomizer
PreciseInhale ® Nebulizer provides a comprehensive solution for aerosol atomization, whether it is dry powder DPIs、pMDIs， Or other liquid aerosols can
Product details
PreciseInhale ® Nebulizer provides a comprehensive solution for aerosol atomization, whether it is dry powder DPIs、pMDIs， Or other liquid aerosols can achieve precise aerosol control and can be applied to various aerosol exposure experiments, such as oral and nasal inhalation, tracheal inhalation, cell toxicity, ex vivo lungs, artificial blood gas barrier research, etc.
PreciseInhale ® Being able to quickly and accurately control aerosol generation, and provide precise and prospective dose data, greatly reducing in vivo or in vitro experimental errors and lowering risks.
Product features:
·Small standard deviation: The typical standard deviation of aerosol data is less than 10%, while traditional methods can even reach up to 100%;
·Low drug consumption: Only 100mg or less of the drug is needed for complete pharmacokinetic experiments, reducing the consumption of precious drugs;
·Quality rather than quantity: In vitro modules can achieve high-precision control of drug dosage for individual animals and provide precise and clear dosage data, saving animal usage;
·Uniform aerosol particles: Both internal and external modules can generate uniform aerosol particles, greatly reducing detection errors and producing comparable data.
Unlike high-pressure injection, PreciseInhale's unique and precise administration method can generate a mild and controllable aerosol flow, enabling continuous control and monitoring of aerosol concentration and respiratory patterns of each animal.
Unique internal module
Tracheal module: Tracheal modules can bypass the oral and nasal airways to directly expose drugs to the lungs. They almost do not waste test materials and evenly distribute aerosols in the lungs
✓ Individual controlled inhalation dose;
✓ Standard deviation<10%;
✓ Generate pharmacokinetic absorption curves of the test substance in systemic blood flow.
Unique external module
The in vitro dissolution and absorption module uses an artificial blood air barrier with precise temperature control at 37 ℃ to generate predictive iViVC data:
✓ Drug dissolution and absorption data;
The Cmax and Tmax data of drug absorption are very similar in clinical absorption;
Real time storage of optical microscope photos and videos during the dissolution process;
✓ Identify and rank the test drug, compare the generic drug formula with the original drug.
PreciseInhale is an advanced aerosol generation system that can be widely used for precise administration of in vitro and in vivo exposure modules. Aerosols can come from dry powders, various inhalers, or nebulizers:
The DissolvIt module presents the absorption curves of candidate drugs and the original drug
DissolvIt ® The module is a breakthrough product in the iViVC field, providing highly prospective data on drug solubility and absorption, enabling accurate early identification and ranking of candidate drugs, accelerating drug screening and development processes.
PreciseInhale redefines the 3R standard
Reduce - precise control to reduce animal/drug usage
The single animal precise exposure method significantly reduces the standard deviation of lung deposition dose, which greatly reduces the number of animals required for inhalation studies compared to traditional "tower" exposure systems;
✓ High precision particle control, uniform distribution of sample particles, only 100mg of drug is needed to complete the complete pharmacokinetic experiment, reducing the amount of precious drugs and saving experimental costs;
Replace - Modules are replaceable and widely applicable
✓ In vivo experimental module for precise control of drug dosage, reducing animal usage
✓ Double in vitro module high-precision simulation of in vitro conditions, used for drug screening and evaluation, cell toxicity, etc
✓ Multiple sample atomization modules provide broad drug applicability
Refine - Fine tuning, low-pressure delivery, uniform distribution
✓ Effectively separate the powerful energy generated by aerosols from drugs, allowing aerosols to be transported with lower pressure. The gentle delivery method provides a more precise and controllable dose while ensuring a more even and precise distribution within the lungs
reference:
1.Delivering horseradish peroxidase as a respirable powder to the isolated, perfused, and ventilated lung of the rat: the pulmonary disposition of an inhaled model biopharmaceutical；
PreciseInhale ® – Isolated Perfused Lung (IPL)
2.Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology；
PreciseInhale ® – Isolated Perfused Lung (IPL)
3.Dry powder inhalation exposures of the endotracheally intubated rat lung, ex vivo and in vivo: the pulmonary pharmacokinetics of fluticasone furoate；
PreciseInhale ® – Isolated Perfused Lung (IPL)
4.In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro design, lung physiology and kinetic output of models；
DissolvIt ® – Dissolution tests
5.Dry powder inhalation exposures of the endotracheally intubated rat lung, ex vivo and in vivo: the pulmonary pharmacokinetics of fluticasone furoate
PreciseInhale ® – in vivo exposure
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yuyanbio
： yuyanbio
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